Cancer is a major public health problem in developed and developing countries, accounting for more than six million deaths each year, accounting for about 12% of all causes of death in the world. Developing countries are disproportionately affected by disease growth, more than 70% of cases occur in Africa, and about 70% of deaths. The situation is expected to worsen due to population aging in these countries, as well as poor access to prevention and early detection. In Cape Verde and Mozambique, both countries facing an epidemiological transition, cancer has become an important public health problem. Many cases are diagnosed at an advanced stage of the disease, placing emphases on the preventive measures, screening for the early diagnosis and adequate treatment for the improvement in the survival of patients. Since 2013 in Mozambique and 2016 in Cape Verde, the Calouste Gulbenkian Foundation supports an integrative response to contribute to the reduction of cancer mortality and to improve the quality of life of these patients. The focus of the projects are in the training of specialized human resources, improvement of clinical equipment and means of diagnosis, and raising awareness of the magnitude of cancer. In this roundtable the participants will present the rational, work developed and difficulties in the implementation of a multiyear plan in these two distinct contexts – Cape Verde and Mozambique.