This session will provide an overview of the coordinated development, structures and procedures for the Beginning Investigator Grant for Catalytic Research Grants (BIG CAT) program for 2020 and beyond. BIG CAT 2.0 is a cooperative endeavor of AACR, AORTIC, Harvard Medical School, and Takeda Oncology which share the goal of sustaining the grants program to assure its lasting value and prestige within the world of science and beyond. Session content will include details of the program’s scope, the administration of applications and awards, and the provision of associated awardee training, mentorship, and network development.