The concept of value is increasingly recognised as an essential component in the delivery of high quality cancer care. This concept has relevance in all health systems but is particularly important in low resource settings. In the past five years there have been major initiatives by the American Society of Clinical Oncology (ASCO), the European Society of Medical Oncology (ESMO), and the World Health Organization (WHO) to identify cancer therapies that offer meaningful benefits to patients. These efforts have been complimented by the Choosing Wisely movements in India and sub-Saharan Africa. This presentation will provide an overview of how these initiatives can promote sustainable, high quality cancer care globally. Population-based cancer health services research will also be highlighted as a tool that can offer critical insights into the extent to which cancer therapies and health systems offer real benefit to real patients in the real world. Examples of such studies from LMICs will be used to illustrate potential collaborative projects that may be launched through the AORTIC network.